到1996年年底，美国艾滋病病毒的直接治疗费用超过了51亿美元。到1997年年中，仅在那一年的6个月里，花费就超过了67亿美元，平均每个病人2万美元。参见Bozette,S. A., Berry, S. R., Duan, N., et al., “The care of HIV-infected adults in the United States.” New England Journal of Medicine 339 (1998): 1897-1904。
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715.Garrett, L., “AIDS drugs fading: New prevention approach sought.” Newsday(August 31, 1999): A4; and Wainberg, M. A. and Friedland, G., “Public health implications of antiretroviral therapy and HIV drug resistance.” Journal of the American Medical Association 279(1998): 1977-1983.